Wire electrical discharge machining (WEDM) is unconventional method commonly used for manufacturing of components with difficult shapes or profiles. It is very useful for machining very small – micro components with high dimensional accuracy and quality of surface finish. This technology allows even cutting of very hard materials, provided they are conductive. First part of this paper deals with machining aluminium alloy AlZn6Mg2Cu, setting of cutting parameters and measuring properties such as surface roughness and cutting width (kerf) of the machined samples. The second part is focused on studying of machining process using design of experiments (DOE) methods and analysis of variance (ANOVA), especially for identifying of key parameters that have influence on the WEDM process. The aim of this work is to explore the possibility, whether if by performing planned experiment and subsequent evaluation in the future allows determining exactly setting the key parameters influencing the process of WEDM.