This paper deal with comparison of mechanical properties of composite sandwich panel with aluminium honeycomb core which is determined by experimental measurement, analytic calculation and numerical simulation. The goal was to compared four composite sandwich panels. The composite sandwich panels were made of two different aluminium honeycomb cores with density 32 and 72 kg.m-3 and two different layup of skin with 4 and 5 layers. The comparison was performed on a three-point bend test with support span 400 mm. This paper confirms the possibility of a very precise design of a composite sandwich panel with an aluminium honeycomb core using analytical calculation and numerical simulation.