The production of individual work pieces in small to medium batch sizes requires an adaptation of the manufacturing strategy. Particularly, the manufacturing of multi-material components out of metal and plastic is characterized by high production costs as well as high production times. To resolve this challenge, a new, modular process chain for the production of these structures in a single manufacturing cell was developed. In this cell, a robot manufactures multi-material components with multiple end-effectors in several successive process steps. In the first step, interlocking structures are manufactured on a metal part by a surface structuring tool. Afterwards, an extruder is used to add a thermoplastic onto the structured metal part. Due to mechanical interlocking effects, the applied thermoplastic shows improved adhesion behavior. A study was conducted to analyze the achievable joint strength of the additive material application onto the structured metal samples. Investigations to determine the achievable manufacturing quality of a robot guided milling process for multi-material parts have been carried out. A recently developed suction hood is used to capture the metal and plastic chips. In this paper, the results regarding the efficiency of the individual end-effectors, including the extraction hood, are presented and it is demonstrated how they interact within the robot-based process chain.