The article deals with some aspects and uncertainties of the design and operation of low pressure sewer systems. The most frequently used types of pumps are compared in the text with respect to the design parameters and impact to the hydraulic analysis of the pressure system. Also different methodologies of estimation of design flow are compared with the flow that was measured on the real low pressure sewer. The document describes the currently ongoing project of applied research, which focuses on optimizing the operation of pressure sewerage systems.