Creep-resistant martensitic steel X10CrWMoVNb9-2 (P92) is suitable for high-temperature application used in the ultra-supercritical (USC) power plants at temperatures within the limits from 600 to 620°C and pressures about 26 MPa. It is steel alloyed with vanadium and with controlled content of boron and nitrogen. The aim of this paper is to describe how can be optimized welding processes by means of the numerical simulations mainly with respect to the structural changes and hardness in the HAZ. On the real multilayer weld will be described how to arrange whole experiment in order to obtain not only relevant input data but also verification data. Additional aim of this paper is to propose mathematical description of the computational model that is usable for simulation computations of welding and heat treatment of real structure components.